The structures of were determined by interpretation of their 1d and 2d nmr spectroscopic data as well as hresims values. However, the effects of sbf on impaired learning and memory. A new polyphenolic glycoside from scutellaria barbata. However, the immunomodulatory function of sbe on the tumor growth of hepatoma remains unclear. Jun 15, 2019 a new polyphenolic glycoside 1, together with three known compounds 24, was isolated from scutellaria barbata by repeated column chromatography.
Hi melinda, thank you for mentioning the scutellaria barbata. Neoclerodane diterpenoids from scutellaria barbata with. Pdf enhanced anticancer effects of scutellaria barbata d. Phytotoxic neoclerodane diterpenoids from the aerial parts. Jan, 2017 previous studies showed scutellaria barbata d. Don is a perennial herb plant of the genus scutellaria in the lamiaceae, distributed widely in china, korea, india, and other asian countries, and is popularly used in china as a traditional medicine for the treatment of various diseases yeon et al. Scutellaria barbata has a long history of medical use in traditional chinese medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to. Total flavonoids of scutellaria barbata inhibit invasion of. Antileukemic activity of the chemical constituents from scutellaria. Comparative genome analysis of scutellaria baicalensis and scutellaria barbata reveals the evolution of active flavonoid biosynthesis preprint pdf available february 2020 with 58 reads. An extract of this plant, bzl101, has been shown to have anticancer properties in a variety of human cancers. Stems erect, 123555 cm tall, glabrous or sparsely appressed pubescent upward.
A new polyphenolic glycoside 1, together with three known compounds 24, was isolated from scutellaria barbata by repeated column chromatography. The lowgrowing plant bears flowers that vary from blue to purple. Six new neoclerodane diterpenoid alkaloids, named scutehenanines a. Their structures were established on the basis of detailed physical data analyses. This herb really grows well for us and i think it is somewhat stouter and tougher than most of the other species of skullcap. In order to determine its efficacy on human reproductive cancers, we assessed the responses of two human breast cancer cell lines, estrogen sensitive mcf7 and estrogen insensitive mdamb231, and of two human prostate cancer cell lines. Scutellarein from scutellaria barbata induces apoptosis of human colon cancer hct116 cells through the rosmediated mitochondriadependent pathway. Scutellaria barbata flavonoids sbf, which are isolated from the aerial parts of s. Dglucopyranosyl2r34hydroxy3,5dimethoxyphenylpropanediol 1 by spectroscopic data 1 h nmr, c nmr, hsqc, hmbc, and ord and chemical method.
Both the root and the aboveground part of scutellaria barbata have been used to make herbal medicines. Treating liver disease by chinese medicine has become the focus of current research. As a popular traditional medicinal herb banzhilian listed in the chinese pharmacopoeia, it has a therapeutic history extending back over thousands of years. Click below on a thumbnail map or name for species profiles. Three new neoclerodane diterpenoids along with 12 known compounds 415 were isolated from a methanol extract of the aerial parts of scutellaria barbata. Ofthe30herbstested,onlyscutellaria barbata demonstrated 100% in vitro activity against xdrab. Two novel neoclerodane diterpenoids from scutellaria barbata. Scutellaria baicalensis memorial sloan kettering cancer center. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata a was deduced using roesy data and the computational dft method. The record derives from wcsp data supplied on 20120323 which reports it as an accepted name record 188943 with original publication details. Skullcap, barbat scutellaria barbata potted plant, organic.
These findings provided experimental evidence for the application of sb in the treatment of lung cancer. Pdf using the chinese herb scutellaria barbata against. Comparative genome analysis of scutellaria baicalensis and. Key words included scutellaria barbata, ban zhi lian, cancer, and tumor. Don sb, an antiinflammatory and an antitumor chinese herb, including flavonoids and scutebarbatines on tumor growth and its immunomodulatory effects in vivo. Don, a perennial herb belonging to the family lamiaceae, is widely distributed throughout china and korea, which has been traditionally used in folk medicine as antitumor. Don is a popular chinese medicinal plant documented to treat cancer patients in traditional chinese. In order to determine its efficacy on human reproductive cancers, we assessed the responses of two human breast cancer cell lines, estrogen sensitive mcf7 and estrogen insensitive mdamb231, and of two human. A phase 1b dose escalation trial of scutellaria barbata medicina. Phytotoxic neoclerodane diterpenoids from the aerial parts of scutellaria barbata.
Scutellaria barbata, the barbed skullcap, is a species of flowering plant in the mint family, lamiaceae. The anticancer effects and mechanisms of scutellaria barbata d. Antileukemic activity of the chemical constituents from scutellaria barbata d. This paper summarized the application of scutellaria barbata in liver disease. Uses, benefits, cures, side effects, nutrients in scutellaria barbata.
Don sb is commonly used to treat different types of cancers, but its molecular mechanism of action is not. Studies on its potential anticancer effects are underway. Research article open access antiangiogenic effect of. Bzl101 is an aqueous extract from the scutellaria barbata plant shown to have anticancer properties in a variety of human cancers. Novel antioxidant neo clerodane diterpenoids from scutellaria barbata. This study aimed to investigate the antitumor effects of sbe on hepatoma h22bearing mice and explore the underlying immunomodulatory. It is in flower from may to july, and the seeds ripen from june to august. Scutellaria barbata belonging to the genus scutellaria l. What are the benefits of scutellaria baicalensis scutellaria baicalensis, also known as chinese skullcap, is a perennial flowering plant highly prized for its reputed medicinal properties. A chinese herb that belongs to a group of herbs named scutellaria scullcap or skullcap. It is a perennial herb generally reaching up to 35 centimeters tall, sometimes taller. Liver diseases threat to human health,affecting the quality of peoples lives. Mpro full text journal articles by author kun gao page 1.
Immunomodulatory effect has been found to be an important therapeutic measure for immune responses against cancer. Hangying li, wenjun wei, kailiang ma, jieyao zhang, ya li, kun gao, bioactivity guided the isolation of extracts from the aerial parts scutellaria barbata d. Don references edit prodromus florae nepalensis, sive enumeratio vegetabilium, quae in itinere per nepaliam proprie dictam et rgiones conterminas, ann. Orders which have already been placed will be dispatched as soon as possible.
Antitumor effects of traditional chinese medicine targeting. It has also been shown to be safe in a clinical trial of women with advanced breast cancer, and to inhibit cell proliferation and induce ca. D 1, 4, 5, 6, 6oacetylscutehenanine a 2, and 6o2carbonyl3methylbutanoylscutehenanine a 3, were isolated from the whole plant of scutellaria barbata. The species is hermaphrodite has both male and female organs. Scutellaria barbata family labiatae and some other species from the same genus have been widely used in china, india, nepal. Aug 15, 2010 bzl101 is an aqueous extract from the scutellaria barbata plant shown to have anticancer properties in a variety of human cancers. Banzhilian, a traditional chinese herb with the scientific name scutellaria barbata d.
Don is a popular chinese medicinal plant documented to treat cancer patients in traditional chinese medicine tcm. Here, we reported two chromosomelevel genome assemblies of s. Chinese skullcap is one of the 50 fundamental herbs of traditional chinese medicine. Scutellaria baicalensis, known as chinese skullcap or baikal skullcap, is native to the mountains of eastern asia. Don to discover neoclerodane diterpenoids with potent phytotoxic activity. Antiangiogenic effect of the total flavonoids in scutellaria. Don is effective in the arrest of cancer cell growth in the g1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers.
Evidencebased complementary and alternative medicine hindawi. Scutellaria barbata belonging to this genus is natively distributed throughout southern china. Us77006b2 scutellaria barbata extract for the treatment. It should not be confused with scutellaria baicalensis. Scutellaria baicalensis and scutellaria barbata, common medicinal plants of the lamiaceae family, produce specific flavonoid compounds with antioxidant and antitumor activities, including baicalein, scutellarein, norwogonin, wogonin, and their glycosides. Don is an accepted name this name is the accepted name of a species in the genus scutellaria family lamiaceae. Aug 14, 2017 the arial parts of scutellaria barbata d. It is used along with other herbs in traditional chinese medicine to treat bacterial infections, hepatitis, and tumors, and is also used as a diuretic. Don sbd, is a perennial herb which is natively distributed in northeast asia. In this study, we evaluated the inhibition of scutellaria barbata d. Research article open access antiangiogenic effect of the. From scutellaria barbata to bzl101 in cancer patients. School of pharmacy, chengdu university of traditional chinese medicine, chengdu 6117, china. Scutellaria barbata as commonly used in clinical medicine,has been widely used in the treatmentrelated liver disease.
Names of scutellaria barbata in various languages of the world are also given. Bzl101, a phytochemical extract from the scutellaria barbata. The trial was an openlabel, phase 1b, multicenter, dose. Thus, this herb has been clinically used for treating inflammatory diseases and cancer. Anticancer activity and mechanism of scutellaria barbata. This study aimed to investigate the antitumor effects of sbe on hepatoma h22bearing mice and explore the underlying. Scutellaria barbata herb uses, benefits, cures, side effects. Hedyotis diffusa plus scutellaria barbata and scutellaria barbata plus sanzhongkuijiantang were the most common combinations of two hfs used for breast cancer treatment table 4 with a prevalence support factor of 10. How scutellaria barbata is effective for various diseases is listed in repertory format. All isolated compounds were tested for their inhibitory effects on lpsinduced nitric oxide production.
A botanical new investigational drug for breast cancer. Their structures were determined on the basis of nmr and hr. Scutellarein from scutellaria barbata induces apoptosis of. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Don lamiaceae efficiently inhibited no production in bv2 microglial cells, and the active constituents were further isolated based on activity. Don is believed to clear away heat and toxic material. Scutellaria barbata is a perennial herb prevalent in korea and southern china. Constituents from scutellaria barbata inhibiting nitric oxide.
Don extract sbe is a potent inhibitor in hepatoma and could improve immune function of hepatoma h22bearing mice. Labiatae is a perennial herb which is natively distributed throughout korea and southern china. Don, have been shown to alleviate fever, inflammation, peroxidation, as well as improve memory deficits and neuroendocrine and abnormal free radical changes in ovariectomized rats 79. Scutellaria barbata memorial sloan kettering cancer center. List of various diseases cured by scutellaria barbata. China, in september 2006, and was identified by professor yanyan zhao of the school of pharmaceutical science, yantai university.
Don was collected in linyi district, shandong province, p. Cytotoxic neoclerodane diterpenoids from scutellaria barbata. Pdf novel antioxidant neo clerodane diterpenoids from. Scutellaria barbata name synonyms scutellaria adenophylla miq. Long a mainstay of traditional chinese medicine, skullcap. Scutellaria baicalensis is used in traditional medicine to treat many medical conditions. This herb is known as banzhi lian in tcms which has been used to inhibit inflammatory dai et al. New norditerpenoid alkaloids from scutellaria barbata. Scutellaria barbata, ban zhi lian, cancer, and tumor. Don labiatae is a medicinal herb that has long been used as an antitumor agent in the peoples republic of china and korea. Hedyotis diffusa combined with scutellaria barbata are the.
Application of scutellaria barbata in liver diseases. Scutellaria barbata has a long history of medical use in traditional chinese medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Scutellaria barbata flavonoids alleviate memory deficits and. Scutellaria barbata is an herb that grows in korea and southern china. It has also been shown to be safe in a clinical trial of women with advanced breast cancer, and. The lightly toothed leaves are somewhat lanceshaped or triangular and up to about 3 centimeters long. Scutellaria barbata barbed skullcap pfaf plant database. This plant often grows in wet meadows, nearby pools and brooks. The plants database includes the following 45 species of scutellaria.
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